Nutrition is an important part of staying healthy and these days good nutrition involves feeding your body nutrients via taking adequate supplements to make up for the pollution and denatured food on our planet. There are many reasons we don’t always get our full supply of nutrition. Sometimes even when we eat well, we find out we are malnourished. It has to do with how much you are actually absorbing from the foods you eat. Also, medication can be responsible for minerals and vitamins being sucked out of our systems at a faster rate than we can absorb them and we end up deficient.
Some medications can interfere with the absorption of the natural nutrients you may think you are getting through your diet. This can then cause health problems that you wouldn’t think would be caused by those medications because they are “supposed” to make you better. It is important to keep a list of all your medications and their dosage in your bag, phone or wallet and the dates you started taking them for emergency situations. This also helps you keep check so you don’t overuse your medication.
It is important to know what your medication is used for and not to just take it blindly. Check with your doctor or pharmacist as to the side effects so if you feel unwell, you can decipher if it’s a result of the medication or you genuinely are unwell. If you use the same pharmacist every time, they will keep track of it for you. Always check to see if medications conflict with each other as this can make you very sick.
Many medications, while treating one part of your illness, can lead to nutrition deficiencies, which cause headaches, cramping, low immunity, depression and can increase the risk of clots and osteoporosis. You may also suffer from such side effects as fatigue, bone weakness, dermatitis, dry skin and acne.
Some everyday medications that can interfere with absorption include tricyclic antidepressants, which affect the levels of vitamin B2 and coenzyme Q10; aspirin, ibuprofen and naproxen. which affect iron, folate, zincand vitamin C; the anti-diabetes drug metformin, which can affect folate, vitamin B12 and coenzyme Q10; and the contraceptive pill, which can affect the levels of B vitamins, vitamin C, magnesium, selenium and zinc.
Antibiotics can also deplete the body of essential nutrients. Penicillin such as amoxicillin can lower potassium absorption, while tetracycline such as doxycycline has an effect on calcium and magnesium. This is why it is important if you are regularly taking medications to at least take a multivitamin every day as these vitamins are not stored in the body and if you don’t get your quota one day, then your body becomes nutrition deficient on that day. Put all the days that you don’t get your quota together and you build up a lot of nutrition deficiencies, which will make you ill.
If we were to sum up allergies with an emoji, it’d be a shrug. We know so little about them, and yet tens of millions of Americans experience allergies of some kind or another throughout their lives. They come. They go. They evolve slowly or shift rapidly. Perhaps the only constant is that they’re becoming more common.
But there is some positive news for allergy sufferers everywhere.
“The only good thing about getting older is that, in many cases, allergies are less prevalent,” says Clifford Bassett, medical director of Allergy & Asthma Care of NY and an allergy specialist at New York University. Changes inside and outside our bodies as we age affect the way we react to potential irritants from ragweed to crab to dogs. Why? Well, that’s a little more complicated, and there’s more than one possible reason that your allergy status just switched.
You outgrew it
Around 60 to 80 percent of kids with milk and egg allergies outgrow them by age 16. Only 20 percent of kids with peanut allergies do so, and only 14 percent of those allergic to tree nuts. Just 4 or 5 percent outgrow a shellfish allergy.
Why? Unfortunately, the answer is that we mostly have no idea. We know some general associations—the earlier a child has an adverse reaction to food, the more like they are to outgrow it—but scientists don’t yet understand why some kids age out of their reactions and others don’t. We do know that early exposure to small amounts of food allergens, especially peanuts, helps prevent allergies in the first place. But we have no idea how to actively reverse them once they happen. If you get allergies as a kid, you just have to wait and see if your tolerances change in the future.
One of the few things researchers have observed is that there does seem to be a time limit to ridding yourself of childhood allergies—if you haven’t outgrown an allergy by your teens, you’re likely to have it for life.
You’re moving to new places
Allergies, especially the seasonal variety, can change a lot over a lifetime, but it might not have anything to do with your body. Every place you live has its own set of allergens, so moving from one town to the next will likely change your allergies too. Teens moving out of their parents’ houses or adults changing jobs may experience a sudden surge of allergies, or sweet, sneeze-less relief.
It also takes time to become allergic to things. You may not feel a reaction to ragweed during your first summer in Tennessee, but have a full-blown allergy the next. That’s because you became sensitized one year and reacted the next. Similarly, you may visit someone with a dog and seem fine, but sneeze constantly the next time you hang out at their home.
You’re just allergy-prone
Some people are just unlucky. Again, we have no idea why, but clearly a subset of humans have immune systems primed to identify allergens as potential dangers, giving those poor folks a whole host of allergies while others go sneeze-free. People with one allergy are far more likely to develop another, and as far as we can tell there’s no way to avoid that unless you prevent exposure altogether. And since most of us don’t want to live in bubbles, that means allergy-prone folks are likely to suffer the sniffles their whole lives.
This is distinct, however, from atopy. Atopy is a genetic predisposition to acquiring allergies that essentially means that nearly everything you come in contact with allergen-wise will become a full-blown allergy. Getting a dog? You’ll be allergic soon. Moving house? Enjoy the new outdoor allergies. Atopic people are also more likely to have eczema and asthma. Corticosteroids can sometimes help, as can allergy shots, but it’s still often a lifelong affliction.
Your body is changing
The link between hormones and allergies haven’t been well studied, but some small studies and anecdotal evidence suggest that your immune system can shift a bit in response to hormonal changes. Like nearly everything hormone-related, this affects people with menstrual cycles the most. “In women, the effect of hormones, such as estrogen, may lead to a worsening of their asthma during different times of the menstrual cycle,” explains Bassett. Puberty, pregnancy, and menopause are also commonly times of allergic change—at least anecdotally, since few studies on the subject exist in the literature. Asthma symptoms definitely change during these shifts in hormonal balance, and female bodies experience more autoimmune diseases and immune responses generally, which seems to indicate that female sex hormones have a significant influence on the immune system.
Bassett also notes that factors like weight gain and obesity can affect your immune system, leading to less well controlled asthma and other allergy symptoms over time. Older adults also tend to have a drop off in the kind of antibodies that instigate allergic responses, which means they may lose their reaction to a food or pollen that they used to react to powerfully. But simultaneously, lots of seniors seem to lose tolerance to foods like shellfish, even if they’d previously been able to eat crab every single day.
Or maybe we just have no idea!
And finally, let’s give one last big shrug for all the other factors that seem to influence allergies that we don’t understand at all. A significant chunk of our most-pressing allergy questions are simply unknown. Luckily, allergy research is exploding right now, so hopefully we’ll have answers to those irritating questions soon. In the meantime, if you’re suffering from allergies, get personalized help. Allergists can identify your particular issues and will suggest treatment options, all of which (if you can afford it) will help you manage your allergies better.
Source: Popular Science
While chronic kidney disease (CKD) clearly affects a child’s physical health, new research suggests that it can also have a negative impact on neurocognitive function, academic performance and mental health. These effects can result in long-term consequences for children with CKD as they transition into adulthood.
The findings, published in the Clinical Journal of the American Society of Nephrology (CJASN), show that childhood CKD may lead to mild deficits across academic skills, executive function, and visual and verbal memory.
For the analysis, researchers examined all of the published evidence on cognitive and academic outcomes in children and adolescents with CKD. Their analysis included 34 studies involving more than 3,000 CKD patients under the age of 21 years.
The findings suggest that children with CKD tend to have low-average neurocognitive and academic outcomes. The global cognition IQ of children with CKD was classified as low-average. Compared with the general population, the average differences in IQ were as follows: -10.5 for all CKD stages, -9.39 for patients with mild-to-moderate stage CKD, -11.2 for patients who underwent kidney transplantation, and -16.2 for patients on dialysis.
Direct comparisons revealed that children with mild-to-moderate stage CKD and those who received kidney transplants scored 11.2 and 10.1 IQ points higher than those on dialysis.
Children with CKD also had lower scores than the general population in executive function and memory domains, and they scored lower in tests of academic skills related to mathematics, reading, and spelling.
“In translating our findings to clinical practice, this research provides relevant information on the areas of need — for example, working memory and mathematics — for which children with CKD may need guidance, practice and assistance, particularly for children on dialysis,” said Kerry Chen, M.B.B.S., at the Centre for Kidney Research, University of Sydney, in Australia.
“It also suggests hypotheses for why the overall intellectual and educational outcomes of children with CKD are reduced compared with the general population, and how best to prevent deficits.”
In an accompanying Patient Voice editorial in CJASN, Lori Hartwell, Founder and President of the Renal Support Network, who has had kidney disease since two years of age wrote, “I recall occasions while on hemodialysis experiencing poor cognition and difficulty retaining information.”
“It is not surprising that children and adolescents on dialysis are at greater risk of such effects. Studies have shown a decline in cognitive function that has been associated with fluid and solute shifts while undergoing hemodialysis.”
10 Shocking Things about Narcolepsy that the Media Doesn’t MentionNarcolepsy isn’t the snoozefest we imagined. It’s a fascinating neurological disorder with aspects of dream sleep sneaking into daily life in odd ways like experiencing hallucinations and being paralyzed head-to-toe.
Surprised? I was too — when I was diagnosed 8 years ago in law school.
Julie Flygare, JD — founder of Project Sleep and author of “Wide Awake and Dreaming: A Memoir of Narcolepsy”
Hi! I’m Julie Flygare, a writer and yogi living with narcolepsy in Los Angeles. Here are the most shocking things you didn’t know about narcolepsy and the media doesn’t mention:
10.Narcolepsy is not a joke.
As a young law student at Boston College, I realized I was having mysterious health issues but — narcolepsy?! “Nooo, that’s just a joke about someone falling asleep standing… I don’t have that!”
Popular films like Rat Race, Deuce Bigalow: Male Gigolo and Moulin Rougefeature comical characters with “narcolepsy” falling asleep mid-sentence while standing. This is not what doctors are looking for to diagnose narcolepsy. Narcolepsy’s sleepiness is often much more invisible and pervasive, and that’s just ONE of five major symptoms. Yet, because of the comedic portrayals, people often laugh when they learn I have narcolepsy, even though I have a serious neurological disorder like epilepsy or Parkinson’s disease.
9.People with narcolepsy do NOT sleep all the time.
Individuals with narcolepsy may fight sleepiness during the day but be unable to sleep at night. “Disrupted nighttime sleep” is a major symptom of narcolepsy. Check out this amazing graphic by Falling Asleep.
8.Emotions may cause scary paralysis.
Everyday emotions like laughter, surprise or annoyance may cause scary temporary muscle paralysis — jerky knee-buckling, jaw slackening(talking like you’re drunk), head bobbing or collapsing to the ground unable to move for 30 seconds to a minute. This is cataplexy, a very serious symptom affecting 70% of people with narcolepsy.
7.Napping is not a luxury.
People with narcolepsy are not “lucky” to take naps, they are experiencing extreme neurological sensations. Napping is often inevitable, unwelcome and difficult to plan for in most school or work settings. I struggle with “nap shame” — feeling embarrassed or weak for napping, even though it’s an essential part of my treatment to be able to work full-time and exercise daily.
6.Narcolepsy involves terrifying hallucinations.
Ever woken up but been unable to move your body? This is sleep paralysis, which happens to 1/3rd of all people, but happens more frequently in narcolepsy. Sometimes accompanied by visual, auditory or tactile hallucinations as REAL as reality. This redefines “living a nightmare”.
5.Doctors don’t know narcolepsy.
According to a recent study, 91% of primary care doctors and 58% of sleep specialists are NOT COMFORTABLE diagnosing narcolepsy. Only 22% of sleep specialists could name all five major symptoms. As a result, people go undiagnosed for 3 to 25 years. Misdiagnoses include epilepsy, depression, and schizophrenia.
4.Sleepiness doesn’t always LOOK sleepy.
Narcolepsy’s sleepiness may manifest as hyperactivity, irritability, moodiness, attention deficits, fogginess, or memory problems. These behavioral and cognitive changes are very real, but not what we think of “sleepiness” — i.e. droopy eyelids, yawning or nodding off.
3.Neurological disorder without a cure.
The leading theory is that narcolepsy may be an autoimmune disorder caused by the loss of cells in the brain (called hypocretin or orexin) which help regulate waking, sleeping and dreaming. There is currently NO cure or replacement for the lost neurons. Patients manage with multiple medications and diligent attention to their health and schedules. No two cases of narcolepsy are exactly alike — what works for one patient may not work for another.
2.Sleepiness is NOT laziness.
The sleepiness of narcolepsy is neurological and uncontrollable and is not a sign of laziness or lack of will power. Imagine staying awake for 2–3 days straight. That’s how a person with narcolepsy feels daily. If I felt like being lazy, I would watch TV or play games. Sleep is not that fun, I don’t even remember it.
1.You know someone with narcolepsy.
Narcolepsy affects 1 in every 2,000 people — 200,000 Americans and 3 million people worldwide, including many children. Narcolepsy is invisible, we may look “healthy” on the outside while fighting internally or behind closed doors. Misperceptions cause many to keep it private. Yet, people with narcolepsy are your friends, neighbors and colleagues.
Loneliness obviously has a powerful role in mental health, triggering symptoms of anxiety and depression when feelings of social isolation take a toll on our emotional wellbeing. The need to surround yourself with loved ones and a fulfilling circle of friends in order to maintain a happy, positive outlook on life is self-explanatory, but what is not often discussed are the potentially damaging effects of loneliness on physical health, as well.
One study published in the British Medical Journal found that feelings of isolation and loneliness in seniors between the ages of 65 and 86 led to a 64 percent increase in the risk of developing dementia, an extraordinary spike in odds highlighting the importance of fostering meaningful relationships at all stages of life. An additional study published in JAMA Internal Medicine reported that seniors experiencing strong feelings of loneliness felt debilitated in their everyday lives, resulting in trouble completing routine activities like bathing, getting dressed, walking and climbing stairs.
A 2013 study from the AARP reports that 40 percent of adults report frequent overwhelming sensations of loneliness, a number that has doubled from 20 percent in the 1980s. “Social isolation is a growing epidemic — one that’s increasingly recognized as having dire physical, mental and emotional consequences,” Dr. Dhruv Khullar, physician at NewYork-Presbyterian Hospital and a researcher at the Weill Cornell Department of Healthcare Policy and Research, wrote for The New York Times last year.
Contrary to popular belief, feeling lonely isn’t always a result of social isolation. Sometimes, it can be a physical symptom beyond our control. Researchers at Brigham Young University published a literature review this year detailing the complex relationship between loneliness and cardiovascular issues like coronary heart disease and stroke. They determined that social isolation increases the risk of cardiovascular disease and that the government and the medical community need to do more about it. “Given projected increases in levels of social isolation and loneliness in Europe and North America, medical science needs to squarely address the ramifications for physical health,” concluded the analysis.
New research is telling is that preventing loneliness is a critical component to staying healthy, much like eating right, exercising, and steering clear of vices like tobacco, drugs, and too much alcohol. The silver lining among all this rather depressing information regarding loneliness and physical health is that making time to be social isn’t just a weekend and after-work indulgence—it’s an essential investment in our overall health.
A new study published in Biological Psychology sheds light on the neurobiological processes that link stress to cravings for cocaine.
“Despite intensive research efforts, drug addiction persists as one of society’s most significant health-related issues, and treatment options are limited,” explained study author John R. Mantsch, the chair of the Biomedical Sciences Department at Marquette University.
“The development of interventions aimed at relapse prevention is particularly important for improved outcomes in patients with substance use disorders. Much evidence suggests that stress is a critical contributor to drug use and relapse. While it is clear that there is a relationship between stress and drug seeking, the exact nature of this relationship and the underlying mechanisms are unclear.”
“The goals of this study were to develop a new model for studying the contribution of stress to drug seeking and to examine the mechanisms in the prefrontal cortex through which stressful stimuli promote drug seeking,” Mantsch said.
Previous research has established a link between stress and drug cravings, and some studies indicate that stress can act as trigger for cravings.
The findings from new study, which was conducted on rats, suggests that stress can set the stage for — but not necessarily directly trigger — cocaine-seeking behavior. Stress appears to set the stage for cravings through its actions on the medial prefrontal cortex, an area of the brain that plays a major role in executive functions such as planning.
“Clinical reports suggest that, rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent,” Mantsch told PsyPost.
“In this paper, we use a preclinical rodent model to demonstrate that, during periods of stress, elevated glucocorticoids mobilize endocannabinoid signaling in the prelimbic prefrontal cortex to attenuate inhibitory transmission and promote cocaine seeking behavior.”
“Our findings establish a novel mechanism through which stress can promote susceptibility to relapse in individuals with substance use disorder and therefore may reveal opportunities for new and more effective treatment strategies aimed at relapse prevention,” Mantsch explained.
But there is still much that scientists don’t understand about the link between stress and drug abuse.
“There are several important questions yet to be addressed,” Mantsch told PsyPost. “First, the time-course of stress effects is suggestive of a glucocorticoid mechanism that this not mediated by the canonical glucocorticoid receptor, which typically functions by regulating gene transcription, resulting in effects that take time to develop.”
“Secondly, the output pathway from the prefrontal cortex that is regulated by stress and mediates drug seeking needs to be confirmed. Third, it is unclear if the effects of endocannabinoids on drug seeking can be reproduced by cannabis exposure. Such an observation could suggest that acute cannabis use can promote relapse.”
“However, it should be noted that in contrast to cannabis effects which will be exerted throughout the brain, the effects of stress on endocannabinoids are likely not uniform throughout the brain,” Mantsch said. “Moreover, THC (the primarily active cannabinoid constituent in cannabis products) and endocannabinoids have different actions at receptors that may predict distinct effects on cortical signaling and behavior.”
“Finally, we are in the process of determining if there are sex differences in the effects of stress and glucocorticoids on relapse susceptibility.”
The study, “Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex“, was co-authored by Jayme R. McReynolds, Elizabeth M. Doncheck, Yan Lib, Oliver Vranjkovic, Evan N.Graf, Daisuke Ogasawara, Benjamin F.Cravatt, David A.Baker, Qing-Song Liu, and Cecilia J.Hillard.
If the embarrassment of talking to your doctor about impotence has kept you from getting a prescription for Viagra, you may be in luck—if you live in the United Kingdom. Regulators there have decided the little blue pill can be sold over the counter, without a prescription, to men 18 and older. Pfizer, the drug’s manufacturer, hopes to have 50mg tablets on shelves by the spring.
The UK regulatory body that made the change, the Medicines and Healthcare products Regulatory Agency (MHRA), said it did so in part to discourage men from buying pills from unregulated online merchants. On the site for Viagra, Pfizer warns that it’s “one of the most counterfeited drugs in the world,” which seems plausible to anyone who’s ever waded through the quagmire of boner pill solicitations in their spam folder.
Fake viagra can contain harmful ingredients—Pfizer says it’s found pills containing blue printer ink, amphetamines (you know, speed), and metronidazole, an antibiotic that can cause an allergic reaction, diarrhea, or vomiting instead of making you tumescent.
"Erectile dysfunction can be a debilitating condition,” Mick Foy, MHRA's group manager in vigilance and risk management of medicines, told the BBC, “so it's important men feel they have fast access to quality and legitimate care, and do not feel they need to turn to counterfeit online supplies which could have potentially serious side-effects.” (Sildenafil, the active ingredient in Viagra, is already available free of charge through the UK’s National Health Service.)
Of course, not every bootleg blue pill contains printer ink, speed, and drywall, and it’s worth drawing a distinction between dangerous fakes and knock-offs that are more threatening to Big Pharma’s profits than they are to public health. (Reuters reports that sales of Viagra have declined since 2012 as Pfizer's patents expired.) The fake drug industry is the shadow side of the above-ground, regulated industry, and by many accounts it’s becoming increasing difficult to police. On any one of the tens of thousands of fly-by-night pharmacy websites, a counterfeit (but perfectly safe and effective) Viagra might be indistinguishable from one that’s potentially harmful. As an eager consumer, you can’t know.
The MHRA wants to steer men away from such sites and toward their neighborhood pharmacist, who will decide whether Viagra is appropriate for each patient who inquires. They can offer advice on whether and how it should be used, and nudge people toward their doctor when necessary. People with liver failure, severe kidney failure, or who have severe heart disease or are at a high risk of cardiovascular disease, or take certain medicines that could interact with Viagra shouldn’t take the blue pull, and it’ll be up to pharmacists to mediate with patients.
That has some pharmacists concerned. Before making its decision, the MHRA had 47 responses to its public comment period; 33 supported making Viagra available over the counter, while one was “unsure.” Among the 13 who didn’t support the plan were eight pharmacists, some of whom were concerned about abuse and misuse of the drug, or that patients might withhold health information in order to get it. The MHRA decided the benefits outweighed those risks.
All of which is well and good, but also academic if you’re living outside the UK, in places where Viagra still requires a prescription. Tonic reached out to Pfizer to see if the company plans to push for over-the-counter status in other countries. The response was not exactly illuminating. “While we do not have information to share on specific Rx to OTC switch programs in the United States, generally we consider prescription drugs—both within the Pfizer portfolio and outside it—for potential switch to non-prescription status,” a Pfizer spokesperson said in an emailed statement. “Our objective is to provide consumers with significantly greater access to medicines with well-established efficacy and safety profiles without a prescription.” And, again, Viagra sales are down globally.
So if you’re a guy in the US waiting for Viagra to be available without a prescription, seems like there’s a sliver of hope. But in the meantime, why not trust your doctor?
A research project that began 20 years ago with an interest in how lithium treats mood disorders has yielded insights into the progression of blood cancers such as leukemia. The research, which centers on a protein called GSK-3, will be published in the Nov. 3 issue of the Journal of Biological Chemistry.
Lithium is considered a highly effective treatment for bipolar disorder and other mood disorders, but it still works in only a fraction of patients and has a number of side effects. Furthermore, its mechanism of action is poorly understood, hampering efforts to improve on it.
In 1996, Peter Klein of the University of Pennsylvania discovered that one of lithium's biological activities was inhibiting GSK-3, an enzyme that modifies other proteins by attaching phosphate molecules, a process called phosphorylation. Lithium's effect on GSK-3 affected the development of animal cells, but it is still unknown what connection, if any, this has to psychiatric disease.
Since then, Klein -- now a professor of medicine at the University of Pennsylvania -- has been investigating many different aspects of GSK-3 activity. "In this paper, we were trying to find out what proteins in the cell are affected by GSK-3 inhibition," Klein said. "We compared cells with GSK-3 to cells completely lacking GSK-3 to ask how other proteins changed."
"Mood disorders are so multifaceted in terms of the pathways and pathologies involved; it's really difficult to pin down a specific pathway," said Mansi Shinde, a former graduate student in Klein's research group who led the new study. "We said: Let's look at what GSK-3 does, and that would maybe lead us toward what lithium does."
The research team used mass spectrometry to compare phosphorylation of proteins from mouse embryonic stem cells with fully functioning GSK-3 to cells in which the gene encoding GSK-3 had been deleted. The resulting massive dataset is called a phosphoproteome -- a comprehensive catalog of proteins that are phosphorylated by GSK-3. Analyzing the data yielded some surprising findings.
Conventional wisdom had suggested that GSK-3 phosphorylates proteins that contain a specific amino acid sequence, but the new phosphoproteome showed that the majority of proteins whose phosphorylation depended on GSK-3 did not contain this sequence. Notably, the phosphorylated proteins included a group called splicing factors, which splice together different sections of messenger RNA, changing the proteins that they encode. Absence of GSK-3 changed the splicing patterns of more than 200 messenger RNAs.
The finding that GSK-3 could affect RNA splicing pointed to an unexpected connection: leukemia. Several factors newly discovered to be phosphorylated by GSK-3 are also known to be mutated in acute myeloid leukemia, a condition in which aberrant splicing causes uncontrolled white blood cell proliferation. This observation could also explain why one of the side effects of taking lithium is increased white blood cell count.
"The effect on the splicing factors and other mutations associated with leukemia was completely surprising to me," Klein said. The group is therefore now pursuing investigations into how GSK-3 affects the growth of healthy and leukemic blood cells.
Shinde and Klein are not yet sure whether GSK-3's effect on RNA splicing explains its role in mood disorders. The effect of GSK-3 on messenger RNA in neuronal cells, with or without lithium, would need to be examined to determine this. The study underlines how investigations into the basic biological function of a drug target can lead in unexpected directions. "[The GSK-3 phosphoproteome] is a really large data set," Shinde said. "It's a resource for the field." "The relevance to leukemia could be direct and something worthy of immediate study," Klein said. "The role in psychiatric disorders is a major interest of the work, but the impact would be down the road, not immediate."
People who die from opioid overdoses are significantly more likely to suffer from chronic pain and depression, according to a new study that highlights the risk of combining opioid pain relievers with benzodiazepines, a class of anti-anxiety medication.
Researchers at Columbia University Medical Center analyzed over 13,000 overdose deaths among Medicaid patients and found that over 61 percent had been diagnosed with back pain, headaches or some other chronic pain condition. Many also suffered from depression, anxiety, bipolar disorder, schizophrenia and other mental health problems.
Significantly, nearly half of those with chronic pain (49%) filled a prescription for opioid pain medication during the last 30 days of their lives, and just over half (52%) filled a prescription for benzodiazepines. Prescriptions for anti-depressants, anti-psychotics and mood stabilizers were also common.
“This medication combination is known to increase the risk of respiratory depression, which is the unusually slow and shallow breathing that is the primary cause of death in most fatal opioid overdoses," said Mark Olfson, MD, a professor of psychiatry at Columbia and lead investigator of the study.
“Most persons with opioid-related fatalities were diagnosed with one or more chronic pain condition in the last year of life. As compared to people with opioid-related deaths without diagnosed chronic pain conditions, the decedents with chronic pain diagnoses were more likely to have also received substance use and other mental health disorder diagnoses. They were also more likely to have filled prescriptions for opioids, benzodiazepines, and other psychotropic medications and to have had a nonfatal drug overdose.”
The Columbia study included opioid overdoses linked to both pain medication and illegal opioids such as heroin, but was limited to Medicaid patients who died between 2001 and 2007. Since that time, opioid prescribing has declined, while illegal opioids and counterfeit medication have become increasingly available on the black market.
Public health officials have only recently started warning about the risks of combining opioids with benzodiazepines, and some insurers now refuse to pay for the medications when they are prescribed jointly.
A recent study of overdose deaths in Florida found that benzodiazepines such as Xanax and Valium killed nearly twice as many Floridians in 2016 as oxycodone. Another study in Pennsylvania also found that overdose deaths involving benzodiazepines exceeded those from opioid painkillers.
The Columbia study was published online in the American Journal of Psychiatry. The study was funded by the Agency for Healthcare Research and Quality, the National Institute on Drug Abuse, and the New York Psychiatric Institute.
Pain News Network
As pretty as they are, real Christmas trees can make you wheeze and sneeze. It's likely not the tree itself that triggers allergies but the microscopic mold spores that can harbor in its branches. If you can't resist buying a live tree despite winter allergies, take it home a week before you plan to decorate it and leave it in a garage or an enclosed porch. Then give it a good shake to try to get rid of any spores.
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